Even though there aren't a lot of advertised positions in your city right now, there are still jobs that are being filled. Writers call this the "hidden job market" and you'll need to be in the networking pipeline to reach these.
In R&D centers worldwide, molecular biologists are working with mechanical engineers. Physicists are engaged in problem-solving with their colleagues in chemistry and fluid engineering. Materials scientists and software engineers are huddled, working on common ground. ... Gradually, the independence of the ivory tower is moving to the interdependence seen most often in entrepreneurial companies.