The U.S. National Institutes of Health (NIH) has issued a notice detailing the impact of sequestration cuts  on its 2013 operations. A post at ScienceInsider  surveys the damage, including a decline of $1.55 billion compared to 2012, 703 fewer research grants, no inflationary awards, and cuts in continuing grants. The ScienceInsider post details the impact on particular institutes and includes several responses to NIH Director Francis Collins' call on Twitter for anecdotes illustrating the sequester's impact on individual scientists and laboratories. You can see many more of these using the Twitter hashtag #NIHSequesterImpact .
The NIH notice also lists two impacts relevant to early-career scientists that are not mentioned in the ScienceInsider post: 2013 stipends for Ruth L. Kirschstein National Research Service Awards will be frozen at 2012 levels, and NIH will continue its commitment to funding new-investigator R01 research grants at rates comparable to established investigators.